Thalidomide can be combined with steroids to treat myelofibrosis.
Thalidomide is a drug that can be used either in combination with steroids or on its own to treat myelofibrosis.
There are now drugs similar to thalidomide or derivatives to thalidomide which may prove to be more effective than thalidomide itself. Some of these drugs are used to treat other diseases and some are under trial. These drugs include:
Thalidomide can be used either alone or in combination with steroids.
Thalidomide combined with steroids can occasionally help with the anaemia and can be very effective in some patients. There is evidence to suggest that in some patients with early myelofibrosis, thalidomide may reverse early fibrous deposits.
Thalidomide works by reducing the blood flow to the marrow and stopping the fibroblast cells from building scar material.
Thalidomide and its derivatives can cause:
This medication is given to people with myelofibrosis in low doses, so it is generally reasonably well tolerated.
Thalidomide is often given in combination with steroids. The main side effects of steroids are:
If used long-term this treatment can lead to bone thinning (osteoporosis) and increase the tendency to develop diabetes.